Correlation Between Vitamin D Status and Bone Mineral Density in Patients With Hemophilia

Virginia Commonwealth University20 enrolled

Overview

Study will look at baseline Vitamin D levels, calcium, albumin, liver enzymes, testosterone, osteocalcin, urine N telopeptides, bone mineral density, nutritional assessment and physical activity assessment of boys with hemophilia A or B (ages 2-20 yrs). Patients with low vitamin D levels will receive therapeutic doses of Vitamin D. At end of one year follow up studies will be repeated.

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Hemophilia A Hemophilia B Vitamin D Deficiency

Interventions

Vitamin D and calciumDIETARY_SUPPLEMENT

Doses will be based on Vitamin D levels

Eligibility

Sex: MALEMin age: 2 YearsMax age: 21 Years

Medical Language ↔ Plain English

Inclusion Criteria: * clinical diagnosis of Hemophilia A or B * ages 2-21 years Exclusion Criteria: * therapeutic vitamin D or calcium supplementation within 3 months of study entry

Locations (1)

Virginia Commonwealth University Health System

Richmond, Virginia, United States

Outcomes

Primary Outcomes

Correlate between Vitamin D deficiency, low bone mass and lack of weight bearing physical activity

Time frame: 1year

Secondary Outcomes

Determine bone mass (density) in hemophilia patients

Time frame: 1 yr

establish dose and duration of treatment with vitamin D

Time frame: 1 yr

Data from ClinicalTrials.gov

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