A Study to Evaluate the Effect of Mipomersen on Cardiac Repolarization Conducted in Healthy Subjects

Inclusion Criteria: * Written informed consent provided before any study-related procedures are performed. * Body mass index (BMI) of 19 to 32 kg/m2 inclusive. * Subjects can not have consumed nicotine or nicotine-containing products for at least 6 months before Screening. * Subjects are nonpregnant and nonlactating, surgically sterile, postmenopausal, abstinent, or subject or partner is willing to use a reliable method of contraception during the study and 5 months after the last dose of investigational product. Exclusion Criteria: * History of risk factors for Torsades de Pointes, known Long QT Syndrome, heart failure, myocardial infarction, angina, or clinically significant abnormal laboratory assessments or family history of Long QT or Brugada Syndrome. * Abnormal screening ECG that is interpreted by the Investigator to be clinically significant. * Use of concomitant medications (prescribed or over-the-counter), without the approval of the Investigator and Sponsor, within 7 days before the first dose of investigational product. * Clinically significant abnormal findings on the physical examination, ECG, blood pressure, heart rate, medical history, or clinical laboratory results at Screening or before dosing. * History of clinically significant allergies or hematological, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, or neurological disease. * Positive test for HIV antibody, hepatitis C antibody, or hepatitis B surface antigen. * Positive test for drugs of abuse, alcohol, or cotinine at Screening or before dosing or history of drug or alcohol abuse or dependence within 1 year before Screening. * History of cancer, with the exception of basal cell carcinoma.