An Australian Study of Mesenchymal Stromal Cells for Crohn's Disease

Inclusion Criteria: * Colonic or small bowel Crohn's disease based on endoscopic appearances and histology * Refractory to induction with infliximab or adalimumab; or have lost response to these agents; or have had side effects precluding their further use * Where there has been loss of response to one of these agents, the other must be tried before being eligible * Crohn's disease activity score (CDAI) 250 or more. * C-reactive protein \>10mg/L * Surgery must have been offered to the subject (if appropriate) and declined * Signed informed consent Exclusion Criteria: * Active sepsis, perforating disease. Coexistent perianal fistulous disease is permitted, providing no co-existent infection within previous 4 weeks * Chronic stricturing disease in isolation * Coexistent CMV disease * Prior history of malignancy * Pregnant or unwilling to practice contraceptive therapy or breast feeding females * Last biologic therapy must be greater than 4 weeks prior, must be on stable corticosteroid dose for 14 days prior, during therapy and for 14 days after therapy, must be on stable immunomodulator dose (eg, azathioprine) for 14 days prior, during therapy and for 14 days after.