Localizing the Epileptogenic Zone With High Resolution Electroencephalography

Central Hospital, Nancy, France115 enrolled

Overview

Multicenter prospective study comparing the diagnosis value of high-resolution EEG and depth-EEG to localize the epileptogenic zone in drug resistant partial epilepsies.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

115

Conditions

Partial Epilepsy

Interventions

High Resolution EEGDEVICE

High Resolution EEG

Stereo-electroencephalographyDEVICE

SEEG

Eligibility

Sex: ALLMin age: 15 Years

Medical Language ↔ Plain English

Inclusion Criteria: * medically intractable patial epilepsy confirmed by video-EEG recordings of epileptic seizures. * Depth EEG (Stereo-EEG) required to delineate the epileptogenic zone and define the surgical procedure. * full informed consent of the patient (or of his/ her legal representative) * 15 year or older patient Exclusion Criteria: * contraindication to cortectomy * contraindication to depth-EEG * indication of epilepsy surgery without depth-EEG monitoring * high grade glioma, arterio-veinous malformations * pregnancy * history of severe cardio-vascular event (coronaropathy, stroke)

Locations (2)

University Hospital of Marseille

Marseille, France

Central Hospital

Nancy, France

Outcomes

Primary Outcomes

Sensitivity and specificity of electrical source localization of inter-ictal and ictal discharges using high-Resolution EEG for localizing the epileptogenic zone (the stereo-electroencephalography will be the reference method)

results of electrical sources localization of inter-ictal and ictal discharges are compared to the epileptogenic zone defined by SEEG

Time frame: 3 years

Secondary Outcomes

inter-observer reliability of electrical source localization of inter-ictal and ictal discharges for localizing the epileptogenic zone.

sources localization of inter-ictal and ictal discharges will be interpreted by two independant epileptologists, blinded to the results of stereo-EEG.

Time frame: 3 years

sensitivity and specificity of high resolution EEG and electrical source imaging for surgical decision

decision of surgery and the limits of the cortectomy established with electrical source imaging will be compared to the decision of surgery and the limits of the cortectomy established with Stereo-electroencephalography.

Time frame: 3 years

Data from ClinicalTrials.gov

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