Effectiveness of the Vasodilator Test With Revatio, Made in Patients With Acute Pulmonary Hypertension

Hospital Universitari Vall d'Hebron Research Institute30 enrolled

Overview

The main objective is to validate the safety and efficacy of intravenous and oral sildenafil in the acute vasodilator test in patients with persistence of, at least, moderate pulmonary hypertension after valvular surgery successfully, with a correct left ventricular function and no valvular disease hemodynamically significant.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Pulmonary Hypertension

Interventions

Sildenafil 20mg oral vs Sildenafil 10mg intravenousDRUG

2 arms to comparation: Sildenafil 20mg oral vs intravenous Sildenafil 10mg

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients clinically stable, at least 1 year after the completion of successful valve surgery, with persistent pulmonary artery systolic pressure\> 50 mmHg, * normal left ventricular function and no significant valvular disease in 2 separate Doppler ultrasound studies at least 1 month. Exclusion Criteria: * Patients with other cardiac and noncardiac diseases will be excluded.

Locations (1)

Vall Hebron Hospital

Barcelona, Barcelona, Spain

RECRUITING

Outcomes

Primary Outcomes

Effectiveness

The main efficacy parameter is the effect on pulmonary vascular vasodilation quantified as decreased Pulmonary Vascular Resistance.

Time frame: one day per patient

Central Contacts

Enric Domingo, Promotor

CONTACT

00-34-93-2746455 edrcg@hotmail.com

Data from ClinicalTrials.gov

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