Influence of Equilibration Rate Constant (ke0) of Propofol on the Effect Site Concentration for Loss of Consciousness

Seoul National University Hospital60 enrolled

Overview

The aim of this study is to validate that an effect compartment concentration for loss of consciousness (LOC) was varied according to different Keo value.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

SINGLE

Enrollment

Conditions

General Anesthesia

Interventions

Diprifusor (Target-controlled infusion)DEVICE

Two TCI devices with different Teo and same Marsh PK model

Orchestra (Target-controlled infusion)DEVICE

Two TCI devices with different Teo and same Marsh PK model

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients undergoing general anesthesia Exclusion Criteria: * Hepatic or renal disease * Drug addiction

Outcomes

Primary Outcomes

Estimated effect-site propofol concentration at loss of consciousness

Time frame: after propofol infusion

Secondary Outcomes

Time to loss of consciousness

Time frame: after propofol infusion

Data from ClinicalTrials.gov

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