An Observational Study of Pediatric Subjects With Globoid Cell Leukodystrophy (GLD)

Inclusion Criteria: Subjects must meet all of the following criteria to be considered eligible for this study: 1. The subject has a documented diagnosis of GLD as evidenced by GALC enzyme activity or a GALC genotype that is predictive of GLD. 2. The subject must have clinical signs and symptoms consistent with the diagnosis of infantile GLD including at least 2 of the following: 1. Chronic difficulty with feeding or unexplained irritability or "fisting" or other signs of abnormal increased tone 2. CT or MRI imaging, if performed during diagnostic evaluation prior to enrollment, consistent with GLD 3. Failure to meet at least 2 age-specific developmental milestones consistent with GLD 4. Loss of deep tendon reflexes or abnormal visual fixation or optic atrophy 3. The subject has documented onset of signs and symptoms consistent with GLD at \<12 months of age and is \<21 months of age at time of study entry. 4. The subject was born at a gestational age of 35-41 weeks. 5. The subject had a birth weight of ≥2 kg. 6. At study entry, the subject must be able to maintain oral nutrition and hydration without the use of supportive measures, defined as use of a feeding tube. 7. At study entry, the subject must be able to maintain ventilation without the use of invasive supportive measures, defined as use of a breathing tube. 8. The subject must be able, in the opinion of the Investigator, to accommodate the protocol requirements, including feasibility of study visits. 9. The subject's parent(s) or legal guardian must have voluntarily signed an Institutional Review Board/Independent Ethics Committee-approved informed consent form after all relevant aspects of the study have been explained and discussed with the subject's parent(s), or legal guardian. Exclusion Criteria: Subjects who meet any of the following criteria are not eligible for this study: 1. The subject has neurologic, hearing or vision impairment, difficulty swallowing or feeding, respiratory complications, behavioral disturbances, or other medical conditions that are not due to GLD and are likely to confound the scientific integrity or interpretation of study assessments, as determined by the Investigator. 2. The subject has received treatment with any investigational drug or a device within the 30 days prior to study enrollment through study completion. 3. The subject has received a cord blood or bone marrow transplant or is planning to receive one during the study. 4. The subject's parent(s) or legal guardian is unable to understand the nature, scope, and possible consequences of the study, or does not agree to comply with the protocol defined schedule of assessments.