To Determine if Sleep Deprivation Results in Increased Esophageal Acid Exposure

Southern Arizona VA Health Care System50 enrolled

Overview

The purpose of this study is to determine if sleep deprivation results in increased esophageal acid exposure in healthy controls and gastroesophageal reflux disease (GERD) patients.

To determine if increased esophageal acid exposure is mediated by altering appetite regulation. To assess if there is any relationship between sleep deprivation and the serum level of TNF-alfa (a protein that can be elevated in inflammation).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Gastroesophageal Disease

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male/Female - 18-80 * 2 or more episodes of heartburn a week for last 3 months Exclusion Criteria: * Previous upper GI surgery * Underlying co-morbidity * Narcotic medications * Psychotropic's and Benzodiazapines medications * Hx of psychological abnormalities * Hx of ETOH in previous 6 mos. * Diabetes Mellitus * Neuropathy * Seizures * Sleep Apnea * Co-morbidity that interfere w/sleep * Women who are pregnant, or childbearing yrs, not on BC

Locations (1)

SArizonaVAHCS

Tucson, Arizona, United States

Data from ClinicalTrials.gov

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