This case-control multicentric study involving fertile and infertile couples aims at evaluating the impact on conception rate of nutritional parameters (biologic, clinic, anthropometric, and food questionnaire).
Infertility affects about 15% of couples. Many factors relating to lifestyle and environment are likely to influence fertility. As an adapted nutrition could prevent 30% of cancers, diet could be essential, but largely neglected, in the prevention of infertility. Some studies tried to explore the impact of diet on male or female fertility, but very few focused on both. The aim of our study is to assess the role of nutrition in both fertile and infertile couples, taking into account most of factors relating to lifestyle. Clinical, anthropometric (BMI, fat mass), biological markers (non specific - glycaemia, lipids, inflammation, electrolytes - and specific - vitamins E, A, C, D, B, including folates and MTHFR polymorphism) and semen analysis, will be combined with validated questionnaires (nutrition, drugs, alcohol, tobacco, physical activity, sleep and stress). The statistical analysis of correlations between nutritional and clinical data will provide information concerning the impact of nutrition on fertility.
Study Type
OBSERVATIONAL
Enrollment
400
Laboratoire d'Histologie- Embryologie - Cytogénétique - CECOS
Bondy, France
Evaluate the nutritional status of fertile and infertile couples (food questionnaire - biologic, anthropometric and clinical balance).
Time frame: 24 hours
Impact of genetic polymorphism on clinical and biological phenotypes linked to food behaviour in infertility context (MTHFR polymorphism for folates metabolism)
Time frame: 12 months
Impact of lifestyle (alcohol and tabacco consumption, physical activity, anxiety and sleep) on diet and fertility
Time frame: 24 hours
Impact of nutritional status on fertility and ART parameters
Time frame: 24 hours
Fertility : time to pregnancy (TTP)
Time frame: in the 6 months
Male infertility : quantitative or qualitative semen abnormalities
Time frame: in the 6 months
Pregnancy and obstetrical pathologies, prematurity, twin birth, weight of the new-born in infertile couples
Time frame: in the 6 months
ART parameters, if appropriate
Time frame: in the 6 months
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