Single-dose Safety Study of APD916 in Healthy Volunteers

Inclusion Criteria: * Healthy males or females ages 18-45 years * Body weight of 50-100 kg (110-220 pounds) * Eligible female subjects will be non-pregnant, evidenced by a negative serum pregnancy test at Screening and a urine dipstick pregnancy test on Day -1 (Check-In); non-lactating; surgically sterile, postmenopausal, or agree to continue to use a medically accepted method of birth control during and for at least 1 month after last study medication administration. * Eligible male subjects will either be surgically sterile (i.e., vasectomy), for at least 3 months prior to screening, or agree to use a condom with spermicide when sexually active with a female partner who is not using an acceptable method of birth control during the study and for 1 month after. Exclusion Criteria * Subject who has donated any blood, or had significant blood loss within 56 days of dosing * History of smoking or tobacco use within 3 months prior to dosing * History of epilepsy or other seizure disorder * Recent history (within 2 years prior to the screening visit) of sleep disorders * History (within 2 years prior to the screening visit) of ADD or ADHD * Traveled across more than 3 time zones within 2 weeks prior to dosing