Open-label, Randomized Trial to Determine the Effect of Icodextrin Versus Dextrose (Dianeal 2.5%) in HOMA IR

Inclusion Criteria: * must be over 18-years old and under 75-years old * Peritoneal Equilibration Test (PET) result of high, high average or low average transport * non-diabetic patient * be in Continuous Ambulatory Peritoneal Dialysis (CAPD) * prevalent patients that have been in peritoneal dialysis at least 30 days * wish to participate Exclusion Criteria: * Have a Charlson score of \>7 and have a life expectancy of less than 12 months * HIV positive * present with peritonitis in the month prior to randomisation * present with cardiovascular, metabolic or infection complications that have required hospitalisation in the month prior to the randomisation * have active cancer * pregnant women * patients with known allergy to starch-based polymer * patients who have a significant psychiatric disorder or mental disability that could interfere with the patient´s ability to provide Informed Consent and comply with the protocol procedures * women incapable of maintaining an effective and accepted contraception method