The purpose of this trial is to evaluate the anticaries remineralizing potential of a toothpaste containing 500 ppm fluoride plus fTCP technology relative to a commercially available toothpaste via a double-blind cross-over in situ (or intra-oral) clinical model, whereby approved human participants will wear an orthodontic appliance fitted with an enamel specimen for the duration of a leg (28 days). There will be two test legs.
Study Type
OBSERVATIONAL
Enrollment
30
500 ppm F and 1100 ppm F topical toothpastes comprise sodium fluoride in each.
Dental Diagnostic Clinic within the University of Texas Health Science Center
San Antonio, Texas, United States
Surface Microhardness
Strength measurements made at the enamel surface of the enamel specimen
Time frame: 30 days
Transverse Microradiography
X-ray analysis of enamel lesion
Time frame: 30 days
Cross-Sectional Microhardness
Strength measurements made within the enamel lesion of the enamel specimen
Time frame: 30 days
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