To prospectively test whether the detection of three-dimensional, cast-like polyomavirus aggregates, termed Haufen, in voided urine samples can serve as an accurate biomarker of intra-renal disease, i.e. polyoma-BK-virus nephropathy (PVN). We want to correlate the detection of 'Haufen' with histologic findings made in renal biopsies as well as signs of polyomavirus activation, i.e. viremia and viruria. The prospective study is designed to further validate our retrospective findings (manuscript in press, J Am Soc Nephrology) and more specifically to correlate 'Haufen' shedding with the histologically confirmed course of PVN.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
50
A renal allograft biopsy will be performed when the urine is determined to be Haufen negative.
University of North Carolina-CH Dept of Pathology
Chapel Hill, North Carolina, United States
Correlate Haufen, urine and plasma data with the clinical presentation and - in selected cases - with renal biopsy findings.
Time frame: The biopsy will be performed when urine is determined to be Haufen negative
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.