Cognition and Emotion in the SII and IBD

University Hospital, Grenoble120 enrolled

Overview

The study aims at showing that the susceptibility in the stress is more raised at the person affected digestive pathologies (SII or IBD) in forgiveness than healthy subjects.

The objective of the study which we wish to lead consists in looking for, at the patients SII and IBD in forgiveness, the existence of a correlation between the rate of cortisol(Hormone of the stress) and the level of HRV (Heart Rate Variability) to estimate the inhibitive fronto-amygdalien tonus. So we make the hypothesis that the persons affected by digestive pathologies of type SII or IBD would present an emotional and physiological vulnerability more important than unhurt subjects of pathologies.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

120

Conditions

Irritable Bowel Syndrome Inflammatory Bowel Disease (IBD)Crohn's Disease(CD)Ulcerative Colitis

Interventions

emotionBEHAVIORAL

Show that the susceptibility in the stress (recording of Heart Rate Variability;viewing films;...) is more important at the person affected by digestive pathologies (SII or IBD) in forgiveness than to unhurt subjects of pathologies.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with SII :Membership to the Social Security,SII defined according to the criteria Rome III. * Patients with IBD :Membership to the Social Security,patients with a ulcerative colitis(UC) or a Crohn's disease (CD)ileal and/or colic. Exclusion Criteria: * Existence of a severe affectation on the general plan (cardiac,respiratory,hematological,renal,hepatic,cancerous), * Subject diabetic, * Pregnant or breast-feeding woman, * Subject included in another clinical and\\or therapeutic trial or having been included in a clinical and\\or therapeutic trial for less than a month, * Subject presenting a psychiatric pathology evident, * Person under guardianship.

Locations (1)

Hôpital Michallon-CHU Grenoble

Grenoble, France

Outcomes

Primary Outcomes

RATE PLASMATIQUE OF CORTISOL COUPLED WITH THE CARDIAC VARIABILITY

Time frame: 24 MONTHS

Secondary Outcomes

SCORES OF DEPRESSIVE SYMPTOMATOLOGIE AND ANXIETY, RATE PLASMATIQUES OF CATECHOLAMINES, LEPTINE, ADIPONECTINE AND PRO-INFLAMMATORY CYTOKINES.

Time frame: 24 MONTHS

Data from ClinicalTrials.gov

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