Comparison Between Erythromycin and Neomycin Treatment of Hepatic Encephalopathy

UPECLIN HC FM Botucatu Unesp20 enrolled

Overview

Comparison between the efficacy of two different antibiotics in patients with overt hepatic encephalopathy. The study is randomized, controlled and double-blinded.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Hepatic Encephalopathy Hypertension, Portal Liver Cirrhosis

Interventions

ErythromycinDRUG

250 mg orally q.i.d.

NeomycinDRUG

1 g orally q.i.d.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Hepatic cirrhosis or portal hypertension * Hepatic Encephalopathy Exclusion Criteria: * Acute liver failure * Neuropsychiatric diseases * Inflammatory bowel diseases * Intestinal obstruction * Shock * Renal insufficiency * Alcoholic hepatitis * Alcohol abuse * Antibiotic premedication

Locations (1)

Faculdade de Medicina de Botucatu - Universidade Estadual Paulista

Botucatu, São Paulo, Brazil

Outcomes

Primary Outcomes

Recovery of hepatic encephalopathy

comparison of efficacy between two drugs for the treatment of hepatic encephalopathy

Time frame: three years

Secondary Outcomes

length of hospitalization caused by hepatic encephalopathy

comparison of efficacy between two drugs for reducing the length of hospitalization during treatment of hepatic encephalopathy

Time frame: three years

Data from ClinicalTrials.gov

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