Topical Henna Preparation for the Treatment of Hand Foot Skin Syndrome

Inclusion Criteria: * Patients receiving capecitabine and/or pegylated liposomal doxorubicin as monotherapy or in combination with other agents * New diagnosis of active hand-foot skin reaction (on bilateral hands and/or bilateral feet) of 1-3 toxicity as defined by the NCI-CTCAE version 4.0 grading scale with onset of symptoms within the last thirty days * Patients must be 18 years or older * Patients must provide written informed consent to participate in the study Exclusion Criteria: * Patients with pre-existing dermatological condition affecting the hands or feet that may limit the interpretation of results * Known allergy to natural henna * Patients with a previous history of HFS * History of G6PD deficiency as determined by screening bloodwork