Participation in Procurement of Tissue, Serum, Plasma, Cell Bank, DNA and RNA Samples, and Urine for Biological Studies Related to Prostate Cancer and Prostate Cancer Treatment Follow Up

Inclusion Criteria: 1. Informed consent explained and signed prior to any study related procedures. 2. Age ≥18 years 3. Eastern Cooperative Oncology Group (ECOG) performance status of 2 or better, or Karnofsky performance of 60% or better. 4. Histologically confirmed adenocarcinoma of the prostate within 10 years of study entry. 5. Willingness to return to Mayo Clinic Rochester for follow-up or participate in mail-in PSA processing. 6. Must be disease-free from a previous diagnosis of cancer for a period of time = 5 years excluding cutaneous malignancies of squamous cell or basal cell carcinoma. Exclusion Criteria: 1. Life expectancy \< 5 years. 2. Inability to return to Mayo Rochester for follow-up appointments, sera, and urine collection per protocol. 3. Previous or a concurrent diagnosis of cancers other than basal cell or invasive squamous cell carcinoma of skin within the past 5 years.