NCT01098773 - Pulmonary and Cardiac Ultrasound During Weaning From Mechanical Ventilation | Crick

Overview

Prospective observational clinical multicentric study in ICU with ventilated patients requiring chest ultrasound analysis.

Prospective observational clinical multicentric study on ICU ventilated patients requiring chest ultrasound analysis during weaning from mechanical ventilation with 48 hours of follow-up. Studying variations of cardiac markers

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Adult Patients Ventilated More Than 48 h Stable Respiratory and Hemodynamic Conditions for SBT Consent of Patients Arterial Line

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- Adult patients ventilated more than 48 h * Stable respiratory and hemodynamic conditions for SBT * Consent of patients * Arterial line Exclusion Criteria: * Laryngeal dyspnea * Tracheostomy * Arythmya * No echogenicity * Paraplegia \>T8

Locations (1)

CHU Clermont-Ferrand

Clermont-Ferrand, France

Outcomes

Primary Outcomes

Compare the change in pulmonary aeration during the test of weaning from mechanical ventilation (before, at the end, and 4-6 h after) between patients requiring re-ventilation before the 48th hour, and those weaned permanently.

Time frame: before, at the end, and 4-6 h after

Secondary Outcomes

Studying variations, during weaning from mechanical ventilation, of pressure of left ventricle filling (E / Ea) coupled with those of plasma BNP.

Time frame: in the 4-6 early hours

Assessing the effects of E / Ea and BNP variations on the success or failure in the 4-6 early hours.

Time frame: in the 4-6 early hours.

Compare the variations of lung ultrasound score during the test of the weaning from mechanical ventilation between patients failed the spontaneous breathing test (SBT) and those extubated after successful SBT.

Time frame: in the 4-6 early hours

Comparison of levels epithelial and endothelial markers

Time frame: at h0, h1, h4, h6

Constitution serum bank for epithelial (sRAGE) markers dosages