Bariatric Surgery and Skeletal Health

Massachusetts General Hospital50 enrolled

Overview

Bone loss may occur after bariatric (weight loss) surgery, but standard methods of measuring bone density in obese patients are potentially inaccurate. This study uses quantitative computed tomography to examine changes in bone mineral density after bariatric surgery. We are also studying mechanisms which may explain bone loss after bariatric surgery.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Morbid Obesity

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Either scheduled for Roux-en-Y Gastric Bypass surgery or enrolled in a lifestyle weight management program Exclusion Criteria: * Weight ≥ than 450 lbs * Postmenopausal women * Significant heart, kidney, liver, or malignant disease * Current disorders known to affect bone * Use of medications known to affect bone for more than 7 days in the past 12 months

Locations (2)

Massachusetts General Hospital

Boston, Massachusetts, United States

MGH

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Changes in bone mineral density by dual-energy x-ray absorptiometry (DXA) and quantitative computed tomography (QCT)

Time frame: 1 year

Secondary Outcomes

Changes in serum and/or urine indices of bone formation and bone resorption, such as aminoterminal propeptide of type I collagen [PINP], osteocalcin, C-telopeptide cross-links [CTX])

Time frame: 1 year

Changes in bone microarchitecture by high-resolution peripheral quantitative computed tomography (HR-pQCT)

Time frame: 1 year

Data from ClinicalTrials.gov

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