Estimate the relative bioavailability of co-administered azithromycin microsphere (2000 mg) and the chloroquine (620 mg CQ base) test formulation compared to co-administered immediate release individual tablets of azithromycin (2000 mg) and chloroquine (600 mg CQ base) in healthy adult subjects.
Evaluate the relative bioavailability, assessment of the safety and tolerability of azithromycin microsphere and the chloroquine test formulation compared to immediate release individual tablets.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
NONE
Enrollment
40
AZ microsphere (2000 mg) single dose on Day 1.
Test CQ formulation, 620 mg CQ base, single dose on Day 1.
AZ IR 4 x 500 mg tablets, single dose on Day 1.
CQ 2 x 500 mg (600 mg CQ base) tablets, single dose on Day 1
Pfizer Investigational Site
New Haven, Connecticut, United States
AUClast of azithromycin and chloroquine
Time frame: Through Day 5
Tmax and Cmax of azithromycin and chloroquine.
Time frame: Through Day 5
AUClast, Tmax, and Cmax of desethylchloroquine.
Time frame: Through Day 5
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