Comparison of 18F-fluorodeoxyglucose Positron Emission Tomography and Coronary Computed Tomography in Assessing Vascular Inflammation

Korea University120 enrolled

Overview

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.cardiac multidetector-row CT can provide measurements of coronary artery calcium (CAC), the degree of stenosis, and the characteristics of plaque including its potential vulnerability. Therefore, the purpose of the investigators study is to compare the usefulness of 18 FDG-PET and MDCT in assessing the vascular inflammatory status and vulnerability.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Atherosclerosis

Interventions

Cross section studyOTHER

This is not intervention study. The purpose of the study is to examine the relationship of vascular inflammation assessed by 18FDG-PET and MDCT at the cross section setting

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy patients for visiting routine medical check in our clinic Exclusion Criteria: * History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization) * Diabetes * Stage 2 hypertension (resting blood pressure, ≥ 160/100 mmHg) * Malignancy * Severe renal or hepatic disease * Subjects taking medications that might affect inflammation such as NSIAD and statin

Outcomes

Primary Outcomes

Correlation between vascular inflammatory status measured by 18FDG PET and MDCT

Time frame: 20weeks

Secondary Outcomes

Comparison the correlation with inflammatory marker and vascular inflammatory status assessed by 18FDG PET and MDCT

Time frame: 20 weeks