Satiety Response of Short Chain Fructooligosaccharide

Early Phase 1CompletedNCT01100788

University of Minnesota20 enrolled

Overview

Populations that report high fiber consumption demonstrate lower rates of obesity. Enhanced satiety may play a key role in this relationship. The colonic fermentation of fibers is theorized to influence satiety and food intake. Short chain fructooligosaccharide (scFOS) are rapidly fermentable fibers that can easily be added to foods to impact these parameters. The objective of this study was to evaluate the satiety response of scFOS and its ability to decrease food intake.

Intervention study with fiber added to beverages and acute effects on satiety measured.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Healthy

Interventions

Short chain fructo-oligosaccharide (scFOS) 5 gDIETARY_SUPPLEMENT

Dietary Supplement: scFOS 5 g Novel fiber administered in two 5 g doses--the first in a beverage and the second in a solid chew.

PlaceboOTHER

Treatment without scFOS fiber

Short chain fructooligosaccharide (scFOS) 8 gDIETARY_SUPPLEMENT

Novel fiber administered in two 8 g doses--the first in a beverage and the second in a solid chew.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 64 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy men and women * Age 18-64 years * Non-smoking * Not taking medication * Non-dieting (weight stable in prior 3 months) * BMI 18-27 * English literacy Exclusion Criteria: * Do not regularly consume breakfast * Food allergies to ingredients found in study products * BMI \<18 or \>27 * Diagnosed cardiovascular, renal, or hepatic disease diabetes mellitus * Cancer in previous 5 years (except basal cell carcinoma of the skin) * Any gastrointestinal disease or condition * Recent bacterial infection (\< 3 months) * Recent or concurrent participation in an intervention research study * History of drug or alcohol abuse in prior 6 months * Use of lipid-lowering, anti-hypertensive, or anti-inflammatory steroid medication * Eating disorder * Vegetarians * People who eat more than approximately 15 grams of fiber per day * Women who are pregnant or lactating * Women with irregular menstrual cycles

Locations (1)

University of Minnesota

Saint Paul, Minnesota, United States

Outcomes

Primary Outcomes

Satiety response using visual analogue scales

Satiety response was measured using subjective perceptions of hunger, fullness, satisfaction, and prospective food intake evaluated by previously validated visual analogue scales (VAS).

Time frame: 0, 15, 30, 45, 60, 90, 120, 180, 240 minutes postprandially

Secondary Outcomes

Ad libitum food intake

Time frame: 240 minutes postprandially and over 24 hours

Breath hydrogen response

Time frame: 0, 240 minutes

Gastrointestinal tolerance using visual analogue scales (VAS)

Subjective ratings of bloating, stool consistency, and flatulence on VAS. A stool count was also recorded.

Time frame: 24 hours

Data from ClinicalTrials.gov

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