An Ascending Multiple Dose Study Evaluating AMG 167 in Healthy Men and Postmenopausal Women With Low Bone Mineral Density

Inclusion Criteria: * Low bone mineral density as determined at the time of screening \[as defined by bone mineral density (BMD) T-scores of the lumbar spine (L1-L4), or total evaluable vertebrae (if fewer than L1-L4); or femoral neck between -1.0 and -2.5, exclusive\] * 25-hydroxyvitamin D ≥ 20 ng/mL * Willing and able to take ≥ 1,000 mg elemental calcium and ≥ 800 IU (but ≤ 1,000 IU) vitamin D daily upon enrollment Exclusion Criteria: * Osteoporosis, as defined by BMD T-scores of the lumbar spine (L1-L4) or total evaluable vertebrae (if fewer than L1-L4); or femoral neck ≤ 2.5 * History of vertebral fracture, or fragility fracture (a fracture resulting from no or minor trauma; ie, fall from standing height or less) of the wrist, humerus, hip, or pelvis after age 50 * Diagnosed with any condition that will affect bone metabolism * Diagnosis of clotting factor deficiency or history of bleeding or coagulation disorder * History of spinal stenosis * History of facial nerve paralysis Exclusion Criteria for Cohort 7 Sub-study (Transition to Alendronate): * Contraindicated or intolerant of alendronate therapy