Effectiveness of the Dual Serotonin Norepinephrine Reuptake Inhibitor Desvenlafaxine Succinate in Healthy Volunteers

Inclusion Criteria: * Female subjects between 18 and 40 years of age, including those on oral contraceptive pills * Male subjects between 18-40 years of age * Written informed consent signed by the subject. Exclusion Criteria: * Life-time personal history of diagnosis of major depression according to the DSM-IV (American Psychiatry Association, 1994) using the MINI (Sheehan et al. 1998) * Blood pressure greater than 140/90 and a pulse rate greater than 90bpm * Evidence of significant physical illness contraindicating the use of DVS, found on physical or in the laboratory data obtained during the first week of the study * Obvious mental retardation rendering the response to investigators unreliable * Pregnancy, or absence of adequate contraceptive method. * Concurrent use of psychotropic medication such as antipsychotics, mood stabilizers or regular use of benzodiazepines. * Participation in a clinical trial within 30 days of entry into the current study * Intolerance to Desvenlafaxine