The Effects of Hypolipemic and Antidiabetic Treatment on Cytokines

Inclusion Criteria: * Age (35-64yr) * Primary hyperlipidemia (Total cholesterol \>200mg/dl, Triglycerides \>150mg/dl) * Type 2 Diabetes * For women: * Menopause (\>12 months) * Post hysterectomy * Mechanical contraception * Obtained informed consent Exclusion Criteria: * Secondary hyperlipidemia * Morbid obesity (BMI\>40kg/m2) * Alcohol or drug abuse * Acute or chronic inflammation * Congestive Heart Failure (NYHA III or IV) * Unstable Ischaemic Heart Disease * Moderate or severe hypertension * Cancer in less than 5 years * Chronic kidney disease (stage III-V) * Liver failure * Oral contraception * Not compliant patient * Laboratory results: * alanine transferase (\>3xULN) * creatine kinase (\>5xULN) * haemoglobin (\<10/dl) * PLT (\<100G/l) * WBC (\<3,5G/l or \>10G/l)