Effect of Levosimendan on Respiratory Muscle Function in Healthy Subjects

University Medical Center Nijmegen30 enrolled

Overview

The purpose of this study is to investigate if levosimendan improves contractile performance of the diaphragm in healthy subjects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Respiratory Muscle Function

Interventions

LevosimendanDRUG

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * informed consent Exclusion Criteria: * use of any prescript medication * chronic hiccups * pre-existent muscle disease (congenital or acquired) or diseases / disorders know to be associated with myopathy including diabetes and auto-immune diseases. * pre-existent lung disease * pre-existent cardiac disease (based on history, electrocardiography and transthoracic echocardiography) * pregnancy, breast feeding * upper airway / esophageal pathology * phrenic nerve lesions * any metals in body (pacemaker, splinters, metal stiches)

Locations (1)

University Medical Center Nijmegen

Nijmegen, Gelderland, Netherlands

Outcomes

Primary Outcomes

Contractility of the diaphragm elicited with magnetic stimulation of the phrenic nerves

Time frame: Multiple measurements within 4 hours after administration of study medication

Fatiguability of the diaphragm

Time frame: Multiple measurements within 4 hours after administration of study medication

Data from ClinicalTrials.gov

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