This is a 2-part pilot study in healthy male subjects to evaluate plasma enrichment kinetics of \[13C3,4\]-cholesterol (Part I) and to assess the test-retest reproducibility (Part II) of Reverse Cholesterol Transport (RCT) measurements. The study will determine whether atom percent enrichment (% APE) at 18 hours can be extrapolated from the steady-state value and whether the mean difference in repeat Ra measurements is below is a prespecified level.
Study Type
OBSERVATIONAL
Enrollment
20
%APE (atom percent enrichment) for all study subjects in Part I at 18 hours
Time frame: 18 hours
Rate of appearance (Ra) of unlabeled cholesterol from the whole-body peripheral pool
Time frame: Baseline and 4 weeks
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