A Second Study of NicVAX/Placebo as an Aid for Smoking Cessation

Inclusion Criteria: * Current smoker who smokes at least 10 cigarettes a day during the past year and wants to quit smoking. * Smokers who are in good general health. Exclusion Criteria: * Prior exposure to NicVAX or any other nicotine vaccine. * Use of systemic steroids. * Cancer or cancer treatment in the last 5 years. * HIV infection. * History of drug or alcohol abuse or dependence within 12 months. * Significant cardiovascular, hepatic, renal, psychiatric and/or respiratory disease. * Inability to fulfill all visits for approximately 52 weeks.