Sudden cardiac death remains one of the major leading causes of death. Therapeutic hypothermia is a validated standard procedure to avoid or minimize cognitive deficits after cardiac arrest. To assess the efficiency of different cooling methods and further improve these methods, the investigators collected blood samples to measure the neuron specific enolase (NSE) in patients treated with invasive cooling as compared to patients treated with non-invasive cooling.
Consecutive patients with restoration of spontaneous circulation after resuscitation due to sudden cardiac death were randomized to either non-invasive or invasive cooling for at least 24 hours. NSE was collected at designated time points and compared between patients treated with invasive cooling and those treated with non-invasive cooling. Neurological outcome was assessed between groups at hospital discharge and 6 months after discharge.
Study Type
OBSERVATIONAL
Enrollment
108
University of Leipzig, Heart Center, Cardiology
Leipzig, Germany
University of Leipzig, Heart Center, Cardiology
Leipzig, Germany
neuron specific enolase (NSE) as a parameter for cerebral damage
Blood samples were collected at predefined time-points within 72 hours to measure neuron specific enolase.
Time frame: 72 hours
neurologic outcome
At 6 months after cardiac arrest, the cerebral performance category score is assessed to determine neurologic outcome.
Time frame: 6 months
time to overall survival
At one year after cardiac arrest, overall survival of the cardiac arrest patients is assessed.
Time frame: one year
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