Evaluation of Oxidative Stress and Effect of Levothyroxine Treatment on Oxidative Stress in Hashimoto Disease

Vakif Gureba Training and Research Hospital130 enrolled

Overview

Oxidative stress leads to or accompanies with numerous disease. Oxidative balance in subclinical hypothyroid or euthyroid state in Hashimoto disease are not known. Effect of levothyroxine therapy on oxidative balance are also not known in hashimoto disease.

oxidative stress markers will be measured initially(TAS,TOS,OSI,PARAOXONASE,ARYLESTERASA,PON1 PHENOTYPİNG,LİPİDPEROXİD).After 3 months therapy with levothyroxine measurements will be repeated except PON1 phenotyping.

Study Type

OBSERVATIONAL

Enrollment

130

Conditions

Hashimoto Disease

Eligibility

Sex: ALLMin age: 18 YearsMax age: 95 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age more than 18 years Exclusion Criteria: * inability to give a written consent * other conditions and drug usage affect oxidative stress

Locations (1)

Vakif Gureba Training and Research Hospital

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Poxidative stress markers

Time frame: After levotren therapy

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.