The purpose of this study is to establish the effects of VATS lobectomy for early-stage non-small cell lung cancer. The aims of this study are: 1. To evaluate the early clinical benefits of VATS lobectomy when compared with the axillary thoracotomy. 2. To evaluate the late effects of VATS lobectomy on survival and quality of life when compared with axillary thoracotomy. 3. To establish the normative pattern of VATS lobectomy for early-stage non-small cell lung cancer. 4. To explore the indication of VATS lobectomy for the lung cancer.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
500
video-assisted thoracoscopic surgery
axillary thoracotomy lobectomy
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China
Disease-free survival and overall survival
Time frame: 5 years
Quality of life
Lung Cancer Symptom Scale
Time frame: the first year after the surgery
Postoperative pulmonary function
Time frame: the first three months after the surgery
Postoperative Karnofsky performance status
Time frame: the first year after the surgery
Postoperative Chest Pain
visual analogue scale and Wong-Baker FACES Pain Rating Scale
Time frame: the first year after the surgery
Perioperation data
operation time, intraoperative blood loss, chest tube drainage amount, duration of the chest tube placement, and duratio
Time frame: perioperation
Cytokines response
IL-2,IL-4,IL-6,IL-10,TNF,IFN-r
Time frame: the first 48 hours after the surgery
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