Serum FGF-23 and Vitamin D Deficiency

Istanbul University

Overview

We aimed to determine the effect of vitamin D replacement therapy on serum FGF-23 concentrations in vitamin D deficient women and to compare the FGF-23 concentrations of vitamin D deficient patients with healthy subjects and patients with genetically-determined hypophosphatemic rickets.

Study group was composed of vitamin D deficient females (n =18, mean age 29.1±9.9 yrs), vitamin D sufficient healthy females (control group; n = 19, mean age 28.5±5.2 yrs) and patients with genetically-determined hypophosphatemic rickets (n=13, mean age 26.5±15.1 yrs). Groups were compared for serum FGF-23, 1,25 dihydroxy vitamin D3, calcium, phosphate, bone turnover markers, intact parathyroid hormone and urinary excretion of calcium and phosphate. Vitamin D deficient group was re-evaluated after a standard treatment regimen.

Study Type

OBSERVATIONAL

Conditions

Osteomalacia

Eligibility

Sex: ALLMin age: 9 YearsMax age: 44 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Serum 25OHD Vitamin \<30 ng/mL for group 1 * Serum 25OHD Vitamin \>30 ng/mL for control group Exclusion Criteria: * Receiving medication(s) affecting bone metabolism * History of gastrointestinal disease and malabsorption * History of renal and liver disease

Locations (1)

Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism

Istanbul, Turkey (Türkiye)

Data from ClinicalTrials.gov

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