The study hypothesis is that continuous ND0611 increases the bioavailability of levodopa and therefore the levodopa area-under-the-concentration-curve values, half-life, and trough concentrations The study will help determining the safety and tolerability of ND0611 and determine the pharmacokinetic profile of levodopa following multiple oral dosing of levodopa/carbidopa (LD/CD) and continuous delivery of ND0611
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
8
Hadassah Medical Center
Jerusalem, Israel
Safety and tolerability
Safety and tolerability: * Adverse event reporting * Discontinuation of the treatment due to adverse event
Pharmacokinetics
Pharmacokinetic profile of plasma LD and CD: * Primary endpoint: t½ * Secondary endpoints: through levels, Cmax, Tmax, AUC
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