This study will determine the capacity of more frequent dosing of QAV680 to suppress allergic inflammation. The study will investigate the paradigm of multiple receptor antagonism in allergic disease by combining QAV680 with a second generation H1 histamine receptor antagonist to assess possible additive or synergistic anti-allergic effects of the two compound classes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
60
Novartis Investigative Site
Ontario, Canada
Total Nasal Symptom Score measured during allergen exposure
Time frame: 14 Days
Nasal airway patency assessed by acoustic rhinometry during allergen exposure
Time frame: 14 days
Nasal secretion weight during allergen exposure
Time frame: 14 days
Total Nasal Symptom Score & Total Ocular Symptom Score measured during allergen exposure
Time frame: 14 days
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