The main purpose of this study is to evaluate the effect of increased supply of energy, protein, vitamin A and the long chain polyunsaturated fatty acids docosahexaenoic acid and arachidonic acid on growth, brain maturation and cognitive function.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
50
The control (placebo) group will be fed according to the routines of the participating institutions. The intervention (active) group will receive increased supply of energy, protein, vitamin A and long-chain unsaturated fatty acids.
Akershus University Hospital
Nordbyhagen, Norway
Oslo University Hospital, Rikshospitalet
Oslo, Norway
Oslo University Hospital, Ullevaal
Oslo, Norway
Reduction in discharge rate of small-for-gestational age very low birth weight infants
The primary endpoint is to reduce the discharge rate of very low birth weight infants that are small-for-gestational age, from 60 to 40%.
Time frame: 6 months corrected age
Evaluation of brain function and growth of infant
Secondary endpoints will include: 1. Assessment of brain maturation using MRI. 2. Cognitive measurements. 3. Anthropometric measures and biomarkers to assess body growth and development. 4. Morbidity- (e.g. ROP, BPD, PVL, NEC) and mortality rates.
Time frame: 6 months corrected age
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