The purpose of this study is to investigate the evolution of daytime partial pressure of carbon dioxide in the blood (PaCO2) after 6 weeks of noninvasive ventilation-pressure support ventilation (NIV-PSV) with target volume versus continuous positive airway pressure (CPAP) alone versus NIV-PSV.
Compare the efficacy between 3 ventilation modes (CPAP, PSV and PSV with Target Volume) on patients with obesity hypoventilation syndrome already treated with CPAP but with persistent desaturations.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
The Vivo 40 will be used either in CPAP mode, PSV mode without Target Volume or PSV mode with Target Volume
CHU
Grenoble, France
GH Pitié-Salpétrière - Service de pneumologie et réanimation
Paris, France
Evolution of daytime PaCO2 of NIV without target volume, with Target volume and with CPAP alone
Time frame: 6 weeks
Evolution in dyspnea scores (BDI/TDI and Simon Score)
Time frame: 6 weeks
Evolution of subjective and objective sleepness (Osler)
Time frame: 6 weeks
Cardiovascular parameters on Arterial strength (pulse velocity) and Endothelial function (Post ischemic test)
Time frame: 6 weeks
Evolution of blood inflammation (IL6, TNFα et CRP)
Time frame: 6 weeks
Evolution of insulin résistance
Time frame: 6 weeks
Compliance (hours of treatment)
Time frame: 6 weeks
Evolution of quality of ventilation (Leaks, asynchronism, others events)
Time frame: 6 weeks
Sleep quality (PSG) between the 3 groups at 6 weeks
Time frame: 6 weeks
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