Effect of Folic Acid on Primary Folate Forms in Relation to MTHFR

Universität des Saarlandes75 enrolled

Overview

The common polymorphism in MTHFR gene (C677T) has a significant effect on (6S)-5-CH3-H4folate after folic acid supplementation. For example, post supplementation differences in (6S)-5-CH3-H4folate between CC and TT are above 30%.

The investigators aim to test the effect of low doses of folic acid with or without B6 and B12 on folate forms in relation to polymorphisms in folate catabolising enzymes in elderly people. Our hypothesis is that differences in folate forms after folic acid supplementation might be due to polymorphisms in folate catabolising enzymes. Therefore, folic acid might be retained by people with certain genotypes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

the Effect of MTHFR C677T on Folate Metabolism

Interventions

folic acid plus B6 and B12DIETARY_SUPPLEMENT

folic acid 400 µg plus vitamin B12 plus B6

folic acidDIETARY_SUPPLEMENT

folic acid 400 µg

Eligibility

Sex: ALLMin age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Males and females * Age \> 65 years. Exclusion Criteria: * Renal dysfunction * Recent stroke, or coronary event (within the last 3 months) * Current cancer treatment * Antifolate (e.g. methotrexate) treatment * Ileum resection * Current B-vitamin supplement * Epilepsy medications * Megaloblastic anemia or other indications for treatment with high doses of folate or vitamin B12.

Locations (1)

University of Saarland

Homburg, Saarland, Germany

Outcomes

Primary Outcomes

blood metabolic markers

we will measure primary folate forms after folic acid supplement

Time frame: 18 months

Data from ClinicalTrials.gov

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