Single Ascending Dose Study of BMS-820132 in Patients With Type 2 Diabetes

Inclusion Criteria: * Males and females of childbearing potential (willing to use an acceptable method of contraception), or females of non-childbearing potential (i.e., post-menopausal or surgically sterile) * Diagnosis of type 2 diabetes treated with metformin monotherapy on a stable regimen for at least 2 months * Body Mass Index (BMI) of 18 to 40 kg/m2 * Fasting glucose in the range of 100-250 mg/dL * Hemoglobin A1c (HbA1c) in the range of 6.5% -9.5% Exclusion Criteria: * Clinically significant deviation from normal in medical history, physical examination, ECGs, and clinical laboratory determinations * Any significant acute or chronic medical illness other than stable and well controlled hypertension, microalbuminuria, dyslipidemia, or depression * Past history of diabetic ketoacidosis and/or C-peptide \< 1.0 ng/mL, hyperosmolar nonketotic syndrome, lactic acidosis, or recurrent hypoglycemia * Any major surgery within 4 weeks of study drug administration * Any gastrointestinal surgery that could impact upon the absorption of study drug * Smoking more than 10 cigarettes per day * Recent drug or alcohol abuse * Women who are pregnant or breastfeeding * Positive urine screen for drugs of abuse * Positive blood screen for hepatitis C antibody, hepatitis B surface antigen, or HIV-1, -2 antibody