The purpose of this study is to evaluate the long term immunogenicity produced in children by the investigational hexavalent vaccine (DTaP-IPV-Hep B-PRP-T) given in Study A3L15 (NCT 00362336). Primary Objective: To describe the antibody long term persistence at 3.5 and 4.5 years of age following a 3 dose primary series vaccination of either DTaP-IPV-Hep B-PRP-T or CombAct-Hib™ + Oral poliovirus vaccine (OPV) + Engerix™ B vaccination at 6, 10 and 14 weeks of age and a booster vaccination of DTaP-IPV-Hep B-PRP-T or CombAct-Hib™ + OPV at 15-18 months
All participants must have received the primary series of vaccinations and a booster vaccination in Study A3L15 (NCT 00362336). Participants will receive no vaccination in this study but will undergo immunologic assessments at 3.5 and 4.5 years of age.
Study Type
OBSERVATIONAL
Enrollment
455
Unnamed facility
Bertsham, South Africa
Unnamed facility
Johannesburg, South Africa
The antibody titers for each valence of DTaP-IPV-Hep B-PRP-T vaccine (except poliovirus) post-primary and booster vaccination.
Time frame: Age 3.5 and 4.5 years after infant and booster vaccination
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.