The purpose of this study is to evaluate the effect of 125 mg methylprednisolone, given intravenously 60-90 minutes before abdominal surgery,on the postoperative rehabilitation after abdominal hysterectomy.Sodium Chloride is the placebo. The following parameters are registered: 1. Pain 3, 6 and 24 hours postoperatively and 2-7 days after surgery. 2. The postoperative use of additional analgesics. 3. Inflammatory parameters before and after surgery. 4. Time until mobilization. 5. Time until discharge.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
55
Single dose 60-90 minutes preoperatively
Single dose 60-90 min preoperatively
Department of Gynaechology and Obstetrics, Holbæk Sygehus
Holbæk, Denmark
Pain 6 hours postoperatively
Pain registered by a score on a vas-scale from 0-10 during mobilization and during rest 6 hours postoperatively
Time frame: 6 hours postoperatively
Pain 3 hours postoperatively
Pain registered by a score on a vas-scale from 0-10 during mobilization and during rest 3 hours postoperatively
Time frame: 3 hours postoperatively
Pain 24 hours postoperatively
Pain registered by a score on a vas-scale from 0-10 during mobilization and during rest 24 hours postoperatively
Time frame: 24 hours postoperatively
Pain
Pain registered by a score on a vas-scale from 0-10 during mobilization and during rest once daily from 2nd-7th postoperative day
Time frame: 2-7 days postoperatively
Use of additional analgesics
The use of other analgesics than paracetamol and diclofenac postoperatively - dosage.
Time frame: 0-2 days
Postoperative nausea
Numbers of vomits
Time frame: until 2 days postoperatively
Use of antiemetics
Dosage of antiemetics during the first 2 days postoperatively
Time frame: 0-2 days postoperatively
Time until mobilization
Time frame: 0-2 days
Time until discharge after surgery
Time frame: 0-10 days
Inflammatory parameters
CRP measured 0-24 hours preoperatively before injection of project medicine.
Time frame: 0-24 h preoperatively
Adverse effects
Time frame: 0-2 days
Inflammatory parameter
CRP measured at 10am on the first and second postoperative day.
Time frame: 1-2 days postoperative
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