The purpose of this randomized intervention study is to investigate the effects and biological mechanisms of a supervised 12-week progressive resistance training on fatigue and quality of life in breast cancer patients during chemotherapy. To determine the effect of the exercise itself beyond potential psychosocial effects due to attention by trainers or the group support, patients in the control group have a comparable training schedule (i.e. 60 min, twice a week, for 12 weeks) but with relaxation training (Jacobsen method).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
101
Supervised progressive resistance training
Supervised progressive muscle relaxation training (Jacobsen method)
German Cancer Research Center
Heidelberg, Germany
Fatigue measured by Fatigue Assessment Questionnaire (FAQ)
Time frame: change between baseline and week 13 (end of intervention)
Quality of Life measured by the European Organisation for Research and Treatment of Cancer questionnaire (EORTC-QLQ30/BR23)
Time frame: change between baseline and week 13 (end of intervention)
Depression measured by "Allgemeine Depressionsskala" (ADS, the German version of the Center for Epidemiological Studies Depression Scale (CES-D))
Time frame: change between baseline and week 13 (end of intervention)
Muscle strength measured at the IsoMed2000®
Time frame: change between baseline and week 13 (end of intervention)
Cardiorespiratory fitness measured by ergospirometry
Time frame: change between baseline and week 13 (end of intervention)
Biomarker in blood, urine, and saliva
Time frame: change between baseline and week 6 and 13
Number of patients with adverse events potentially related to the resistance training
Time frame: during the 12-week exercise intervention
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