A study to determine the cardiovascular effects of PF00610335 in healthy volunteers.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
48
An orally inhaled dose of PF-00610355 450 µg on days 1 to 4
An orally inhaled dose of PF-00610355 1200 µg on days 1 to 4
A single oral dose of moxifloxacin 400 mg on Day 4.
Pfizer Investigational Site
Brussels, Belgium
To assess whether multiple dose administration of PF00610335 has the potential to affect QTc in healthy volunteers
Time frame: 24 hours
To assess the effects of a positive control (moxifloxacin) on QTc interval in healthy volunteers
Time frame: 24 hours
To asses the the relationship between plasma concentrations of PF00610335 and its effects, if any on the QTc interval
Time frame: 24 hours
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A single oral dose of non-matched placebo on Day 4.