Alignment Comparison Between TruMatch™ Personalized Solutions and Conventional Total Knee Replacement Instrumentation

Inclusion Criteria: * Subjects meeting all of the following specific criteria will be considered for participation in the study: * Subject is male or female and between the ages of 18 and 80 years old, inclusive. * Subject requires a primary total knee replacement and is considered by the Investigator to be suitable for the specific knee prosthesis identified in the protocol. * Subject has given voluntary, written informed consent to participate in this clinical investigation and has authorized the transfer of his/her information to DePuy. * Subject has given consent to the transfer of his/her information to DePuy. * Subject, who, in the opinion of the Clinical Investigator at the time of preoperative planning, are suitable for implantation using TruMatch™ instrumentation and whose surgical plan (patient proposal) is approved. For example, no femoral nails/bone plates that extend into the knee, i.e. within 8cm of joint line; no metal device that could cause CT scatter about the knee and no deformities greater than 15 degrees of fixed varus, valgus, or flexion Exclusion Criteria: * Subjects will be excluded from participation in the trial if they meet any of the following criteria: * The Subject has, in the opinion of the Investigator, an existing condition that would compromise their participation and follow-up in this study. * The Subject is a woman who is pregnant or lactating. * The Subject is a known drug or alcohol abuser or has a psychological disorder that could affect follow-up care or treatment outcomes. * The Subject has participated in a clinical investigation with an investigational product in the last 3 months. * The Subject is currently involved in any personal injury litigation, medical-legal or worker's compensations claims. * The Subject has previously had a prosthetic knee replacement device (any type including unicompartmental, total knee arthroplasty, patellofemoral arthroplasty) of the affected knee or a previous patellectomy. * The Subject presents ankylosis of the hip joint on the side to be treated or previous ipsilateral UTO/HTO. * The Subject requires simultaneous bilateral total knee replacements. * The Subject had a contralateral TKA and that knee was previously entered in the study. * Subject in whom the surgeon intends to implant a knee prosthesis that is not the cruciate retaining or posterior substituting PFC Sigma total knee arthroplasty. * Subjects who have inflammatory arthritis