A Phase 2 Study of Pertuzumab and Erlotinib for Refractory Pancreatic Adenocarcinoma

Inclusion Criteria: 3.1 Inclusion Criteria 3.1.1 Histologically-confirmed pancreatic adenocarcinoma 3.1.2 One or more locally-advanced or metastatic lesions measurable in at least one dimension by modified RECIST criteria (v1.1)\^13 within 4 weeks prior to entry of study 3.1.3 Prior therapy (1 or more): 3.1.3.1 Disease progression following therapy with gemcitabine 3.1.3.2 Intolerance to gemcitabine 3.1.3.3 Disease recurrence within 12 months following adjuvant gemcitabine 3.1.4 Age \>= 18 3.1.5 ECOG performance status 0-2 3.1.6 Laboratory values \<= 2 weeks prior to enrollment: * Absolute neutrophil count (ANC) \>= 1.5 x 10\^9/L (\>= 1500/mm\^3) * Platelets (Plt) \>= 100,000/mm\^3 * Hemoglobin (Hgb) \>= 9 g/dL * Serum creatinine \<= 1.5 x ULN * Serum bilirubin \<= 1.5 x ULN (\<= 3.0 x ULN if liver metastases present) * Aspartate aminotransferase (AST/SGOT), alanine aminotransferase (ALT/SGPT) \<= 3.0 x ULN. (\<= 5.0 x ULN if liver metastases present). ERCP or percutaneous stenting may be used to normalize the liver function tests 3.1.7 Echocardiogram or MUGA scan demonstrating LVEF \>= 50% within 4 weeks of trial entry 3.1.8 Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: 3.2 Disease-Specific Exclusion Criteria 3.2.1 Prior therapy with EGFR-targeted agents 3.2.2 If history of other primary cancer, subject will be eligible only if she or he has: * Curatively resected non-melanomatous skin cancer * Curatively treated cervical carcinoma in situ * Other primary solid tumor curatively treated with no known active disease present and no treatment administered for the last 3 years 3.3 General Medical Exclusion Criteria 3.3.1 Subjects known to have chronic or active hepatitis B or C infection with impaired hepatic function (ineligible if AST and ALT \> 3.0 x ULN). 3.3.2 History of any medical or psychiatric condition or laboratory abnormality that in the opinion of the investigator may increase the risks associated with study participation or study drug administration or may interfere with the conduct of the study or interpretation of study results 3.3.3 Male subject who is not willing to use adequate contraception upon enrollment into this study and for 6 months following the last dose of study agents 3.3.4 Female subject (of childbearing potential, post-menopausal for less than 6 months, not surgically sterilized, or not abstinent) who is not willing to use an oral, patch or implanted contraceptive, double-barrier birth control, or an IUD during the course of the study and for 6 months following the last dose of second-line treatment 3.3.5 Female subject who is breast-feeding or who has positive serum pregnancy test 72 hours prior to enrollment 3.3.6 Any of the following concurrent severe and/or uncontrolled medical conditions within 24 weeks of enrollment which could compromise participation in the study: * Unstable angina pectoris * Symptomatic congestive heart failure * Myocardial infarction \<= 6 months prior to registration and/or randomization * Serious uncontrolled cardiac arrhythmia * Uncontrolled diabetes * Active or uncontrolled infection * Interstitial pneumonia or extensive and symptomatic interstitial fibrosis of the lung * Chronic renal disease 3.3.7 Patients unwilling to or unable to comply with the protocol 3.3.8 Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study other than a Genentech/Roche sponsored cancer study