Streptococcus Pneumonia: Effects of PCV13 on Pneumococcal Carriage

Boston Medical Center9,000 enrolled

Overview

The specific aim is to evaluate the impact of PCV13 as administered in the pediatric primary care clinic at Boston medical center on the serotype specific carriage of Streptococcus pneumoniae in children \< 5. Specifically the investigators will measure the decline in vaccine serotypes, the proportion of children receiving vaccine required to achieve 50% reduction in serotype specific carriage and the correlation between immunogenicity of the specific serotypes and decline in carriage. The study has been extended to complete 5 years of surveillance to determine the new SP serotype distribution at the time presumably a new equilibrium has been achieved.

Study Type

OBSERVATIONAL

Enrollment

9,000

Conditions

Nasopharyngeal Carriage of S. Pneumoniae

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * children \< 5 years of age receiving care at Primary Care center at BMC and as many parent(s) as willing to participate Exclusion Criteria: * children with facial malformations making NP sampling unacceptable * children in foster care

Locations (1)

Pediatric Primary Care, Boston Medical Center

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Nasopharngeal Colonization With PCV13 S. Pneumoniae

Proportion of PCV13 serotypes among n=1851 children colonized with any S. pneumoniae

Time frame: Study years 1-5