Prasugrel Versus High Dose Clopidogrel in Clopidogrel Resistant Patients Post Percutaneous Coronary Intervention (PCI).

University of Patras70 enrolled

Overview

The use of dual antiplatelet therapy is considered standard of care in patients post percutaneous coronary intervention (PCI) with stenting. However, a significant proportion of patients is considered clopidogrel resistant and this resistance is shown to be accompanied by future adverse events. Additionally, clopidogrel resistance has been linked with the CYP2C19 polymorphism. The hypothesis of the study is to define in consecutive patients undergoing PCI those that are clopidogrel resistant PCI following routinely used loading as estimated predischarge with the VerifyNow point of care system of platelet reactivity. Clopidogrel resistant patients will be randomized in 1:1 fashion to prasugrel 10 mg or clopidogrel 150mg daily. Platelet reactivity will be assessed at day 30, when treatment crossover will be performed. At day 60 platelet reactivity will be determined as well. In addition, in all patients genetic determination of CYP polymorphisms (including the CYP2C19)known to affect clopidogrel metabolism will be performed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Coronary Artery Disease (CAD)Acute Coronary Syndrome (ACS)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥18 years old * Patients having PCI with stenting 24-48 hours prior randomization, for 1. Stable angina 2.Ischaemia in provocative test 3.Acute coronary syndrome (unstable angina or myocardial infarction) * Written Informed consent * Platelet reactivity units (PRU) (VerifyNow) \>230 Exclusion Criteria: * A history of bleeding diathesis * Chronic oral anticoagulation treatment * Contraindications to antiplatelet therapy * Known platelet function disorders * PCI or coronary artery bypass surgery \< 3 months * Unsuccessful PCI (residual stenosis \> 30% or flow \< Thrombolysis in myocardial infarction flow 3) * Planned staged PCI in the next 60 days * Hemodynamic instability * Cancer or hemodialysis * Platelet count \<100 000/ μL, hematocrit \<30% * Creatinine clearance \<25 ml/min * A life expectancy\<1 year, inability to give informed consent * High likelihood of being unavailable for the Day 60 follow up

Prasugrel Versus High Dose Clopidogrel in Clopidogrel Resistant Patients Post Percutaneous Coronary Intervention (PCI).

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes