Screening for Fabry Disease Among Young Stroke Patients in an Israeli Stroke Clinic

Wolfson Medical Center1,000 enrolled

Overview

The purpose of this study is to determine the incidence of Fabry Disease in young stroke patients in an Israeli stroke clinic.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

1,000

Conditions

Fabry Disease in the Young Stroke

Interventions

blood testOTHER

Dry blood spots (DBS) analysis of a- galactosidase-A activity will be used for male patients' diagnosis. Males and females with enzymatic activity bellow the test's cut-off will be further diagnosed by gene sequencing. Since females are heterozygote and may have high residual levels of active enzyme, female patients with a- galactosidase-A activity of 30% bellow averaged normal range will also be further diagnosed by gene sequencing as described before (8).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: diagnosis of stoke or TIA Time period within last 5 years - Exclusion Criteria: Known diagnosis of stroke or index event due to trauma \-

Locations (1)

Neurology Dept. Edith Wolfson Medical Center

Holon, Israel

Outcomes

Primary Outcomes

positive screening of fabry disease

Time frame: past 5 years

Data from ClinicalTrials.gov

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