Assessing Response to Neoadjuvant Chemotherapy With HD PET/CT, Serum Glycomic Markers and Tissue Muc-1 Isoforms

Inclusion Criteria: * Patient must sign informed consent to participate in the study. * Patient must be ≥ 18 years of age. * Histologic diagnosis of invasive breast cancer(ductal or lobular) * Stage II or III breast cancer and considered a candidate for curative mastectomy. * Selected mastectomy for surgical option of treatment. * Patient must agree to receive standard or dose-dense adriamycin, cyclophosphamide, and taxane-based chemotherapy given preoperatively. * Patient must have the following preoperative laboratory values confirmed within 28 days prior to registration: Creatinine ≤ 1.5 times ULN. Platelets ≥ 90,000/mm3. White blood count ≥ 1,500/mm3. PT/PTT ≤ the institution ULN. Patients of child-bearing potential must have a negative urine or serum pregnancy test. * If a patient is a cancer survivor, the patient must have undergone potentially curative therapy for all prior malignancies, with no evidence of prior malignancy for at least 5 years (except for effectively treated basal cell or squamous cell carcinoma of the skin, or carcinoma-in-situ of the cervix treated by surgery alone). * The primary breast tumor must be detectable by mammogram at the time of diagnosis * Estimated cardiac ejection fraction ≥ 50% by echocardiogram or MUGA * ECOG performance status 0-1. Exclusion Criteria: * Non-invasive breast cancer, benign breast disease, or tumor histology other than stage II or stage III invasive ductal carcinoma, invasive lobular carcinoma, or mixed ductal and lobular carcinoma. * The patient has known distant metastatic disease. * The patient wishes to pursue breast conservation. * The patient is male. * The patient is receiving preoperative chemotherapy other than adriamycin, cyclophosphamide, and a taxane (ACT) in standard or dose-dense fashion. * The patient is pregnant or breast feeding. * The primary tumor is not visualized by mammogram at the time of diagnosis. * The patient's estimated cardiac ejection fraction is \<50% by echocardiogram or MUGA. * The patient has a documented intravenous contrast allergy or iodine allergy. * Her-2/neu positive patients by IHC or FISH who receive trastuzumab neoadjuvantly; patients who are Her-2/neu positive but elect not to receive trastuzumab neoadjuvantly are still eligible for participation.