Phosphorous Magnetic Resonance Spectroscopy of Heart

Washington University School of Medicine15 enrolled

Overview

Heart needs constant supply of energy to continue working. Phosphorus magnetic resonance spectroscopy allows us to measure energy produced in the heart. The purpose of this study is to determine if the energy production is reduced in failing heart.

We will use non-invasive phosphorus magnetic resonance spectroscopy technique to measure creatine kinase (CK) flux in failing heart. The studies will be done on Siemens 3.0T human system. We will recruit subjects with LV dysfunction due to prior anterior wall myocardial infarction.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Left Ventricular Dysfunction

Interventions

MR SpectroscopyDIAGNOSTIC_TEST

MR spectroscopy of myocardial

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Individuals with left ventricular dysfunction Exclusion Criteria: * Age \< 18, pregnant, history of excessive alcohol use, or any condition (e.g. claustrophobia, a pacemaker) that would prevent him/her from completing the magnetic resonance spectroscopy study

Locations (1)

Washington University in St. Louis

St Louis, Missouri, United States

Outcomes

Primary Outcomes

An MR Spectroscopy Showing Signal to Noise Ratio to Determine the Level of Heart Failure

Time frame: 1-2 days

Data from ClinicalTrials.gov

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