Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI)

Inclusion Criteria: * Subjects who agree to the terms described in IC; * Subjects of both genders, aged ≥ 18 and ≤ 75 years with IVC framework of the lower limbs; * Subjects with CVI ranked 3 to 5, according to CEAP scale; * Patients complaining of pain and swelling in the lower limbs secondary to IVC; * Subjects with good mental health that can respond adequately to the study questionnaires; * Subjects who agree to make any return visits for evaluation; Exclusion Criteria: * Patients with CVI classified as 0, 1, 2 or 6, according to CEAP; * Subjects who have received treatment for varicose veins as laser, medication use topical or oral (eg: brown India, coumarin, and etc.). And surgery in the 03 months preceding the study; * Patients with other diseases that may interfere with the study results: thrombosis, coagulation disorders and other diseases that the medical criteria, are important to be excluded; * Pregnant or nursing women; * Presence of any medical condition that, according to the investigator, should prevent the patient from the study; * Participation in clinical trials in the twelve months preceding the study; * Patients with serious illnesses and uncontrolled that need multidrug treatment; * Patients on diuretics of any kind, regardless of pathology (hypertension, renal or liver disease); * Values of laboratory tests appropriate security; the Hemoglobin \<10 mg / mL the creatinine\> 1.5 mg / mL; AST, ALT, GGT ≥ 2 times normal values; the platelet count below 90.000/ml; Total Bilirubin and the fractions ≤ 1.5 times the normal range. * past medical history of hypersensitivity to drugs of the same pharmacological classes of substances under investigation;